St. James is located in south central Missouri on U.S. Interstate 44 between St. Louis and Springfield. A small, vibrant community, St. James is know for our area wineries, antique and speciality gift shops and our quaint and unique downtown. Retail establishments, fine restaurants, a thriving business and industrial community, and excellent municipal services contribute to making St. James a great place to live, raise a family, and/or retire. Whether you plan to spend a weekend or a lifetime with us, we know you’ll enjoy the time you spend in St. James – truly the Ozarks’ best.